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Coefficient Giving
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RFP on Alternative Protein R&D

Since 2016, Coefficient Giving has allocated several million dollars toward the development of better and cheaper alternatives to animal products. 

We now see an opportunity to accelerate progress on several fronts, particularly in closing the taste and price gap between alternative proteins and the animal products they aim to replace.

After a decade of investment, the alternative protein category has produced commercially significant products but has yet to achieve mainstream adoption. The dominant hypothesis, as illustrated by consumer surveys and industry, is that taste and price represent the dominant barriers to mainstream adoption. 

For example, plant proteins often have “grassy” or “beany” off-flavors that overwhelm engineered flavor systems. Fat systems built on commodity oils don’t generate the same mouth-feel of animal fat, nor do they adequately replicate the lipid-Maillard chemistry that produces “meatiness” during cooking. Egg replacement has remained largely static, despite increased buyer interest due to avian influenza and feed price increases. Additionally, entire categories of widely consumed fish that are processed into unstructured products like pastes, soups, sauces, and surimi remain poorly understood at the flavor-chemistry level, even though these unstructured formats make them tractable targets for replacement.

These are foundational, pre-competitive research problems. They are unlikely to be solved by any single company, and they are systematically underfunded by both public agencies and private R&D budgets. We think this is precisely the kind of neglected gap that philanthropy should fill.

We expect to spend up to $10 million USD on this RFP and could spend more depending on application quality. 

We’re soliciting proposals across four priority areas: 

  1. Off-flavor reduction in plant- and fermentation-derived protein ingredients, via agricultural, breeding, processing, or fermentation-based interventions; 
  2. Fat alternatives for flavor generation, including oleogels, emulsion systems on existing margarine/spread lines, oil bodies, novel flavor-active lipid compounds, and oilseed breeding for longer-chain monounsaturates; 
  3. Egg reduction and replacement through enzymatic approaches, hybrid systems, and foundational functional characterization in industrial bakery, mayonnaise/dressings, and pasta; and 
  4. Characterizing fish flavors in welfare-priority species, including tilapia and milkfish, carp and bottom-dwellers (including pond loach), and catfish. 

We’ve published a technical context document describing each priority, the metrics we care about, and the rubrics we’ll use to evaluate proposals. Applicants should read this document carefully before applying. Proposals that ignore the metrics and methodology preferences described there are unlikely to be competitive.

We welcome proposals of varying sizes and scopes; individual awards are expected to range from approximately $100,000 to $1 million, with two- to three-year typical durations (3.5 years maximum). We encourage applications from across the R&D ecosystem, including universities and research institutes; small, medium, and large companies; and public-sector research organizations. Successful teams will likely be interdisciplinary, combining expertise across analytical chemistry, sensory science, food science, fermentation, breeding, and/or industry-relevant scale-up. We strongly encourage applications that include industry partners or articulate a credible pathway to industry uptake. Applicants from anywhere in the world are welcome to apply, though award eligibility will be subject to legal and financial due diligence.  

Applications will remain open until Aug 10, 2026. The first and only step is to submit an application. Please read the technical context document carefully before applying. Awards will be announced on a rolling basis, with final decisions shared before November 30, 2026.
Click here to apply

If you have questions about the application process, please email altproteinrfp@coefficientgiving.org. Please note we can’t provide detailed feedback on draft proposals before submission.

  • Start by reviewing the application form, as it may address questions on application requirements and eligibility. You can open the form and view it at any time without submitting, and your progress will be saved. 

    You may also find the following Q&A helpful. If you still have questions not answered in the application form or below, feel free to reach out to altproteinrfp@coefficientgiving.org.

    Note: We’re unable to provide feedback on project fit or to have a call to discuss a project prior to proposal review. 

  • Matching funds are not required. You can view the budget section of the application form for guidance on structuring your budget.

  • There are no specific geographical restrictions on who can apply, although certain jurisdictions might be challenging or impossible to fund, depending on the nature of the project. For non-profit and institutional applicants, our institutional grantee FAQ has more detail on the international compliance process.

    For Indian applicants from universities, please also submit either i) a valid FCRA or ii) proof that you have an FCRA exemption. If you have neither, please submit anyway, and we will investigate whether there are other alternative avenues (though there is no guarantee there will be).

  • Both non-profit and for-profit organizations are eligible, including universities, research institutions, companies, and university-industry collaborations. Any award to a for-profit entity would be subject to due diligence, and the structure of such an award would depend on the scope of the proposed project and its alignment with our charitable mission.

  • Coefficient Giving works with a range of funding entities and structures awards flexibly to maximize impact in line with our charitable mission. Specific terms will depend on the nature of the receiving organization and how any eventual award is structured. We do not share a model grant agreement prior to an award.

    For non-profit and institutional applicants, our institutional grantee FAQ covers general grant logistics. 

    For-profit applicants with specific questions about award structure or IP are welcome to email altproteinrfp@coefficientgiving.org.

  • Please refer to the budget section of the application form for eligible cost categories — you can open and view the form at any time without submitting. Indirect costs are subject to our Policy on Indirect Costs.

  • The application form includes a section where applicants describe their IP management plan — please refer to this for our expectations around IP management. More broadly, IP terms — including any rights to commercialize project outputs — will be determined on a case-by-case basis and will depend on the funding structure, project scope, and alignment with our charitable mission.

    For-profit applicants with specific questions about award structure or IP are welcome to email altproteinrfp@coefficientgiving.org.

  • Yes — applicants are permitted to participate in multiple proposals, whether as PI on more than one proposal or as PI on one and Co-I on others.

  • We’re unable to have calls with applicants or provide feedback on project fit prior to proposal review given the volume of applications. We hope you’ll apply!